{"id":3556,"date":"2023-12-11T00:00:00","date_gmt":"2023-12-10T15:00:00","guid":{"rendered":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/archives\/3556"},"modified":"2023-12-11T00:00:00","modified_gmt":"2023-12-10T15:00:00","slug":"co-option-and-neofunctionalization-of-stomatal-executors-for-defense-against-herbivores-in-brassicales","status":"publish","type":"post","link":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/archives\/3556","title":{"rendered":"Co-option and neofunctionalization of stomatal executors for defense against herbivores in Brassicales"},"content":{"rendered":"<p class='author'>Makoto Shirakawa, Tomoki Oguro, Shigeo Sugano, Shohei Yamaoka, Mayu Sagara, Mai Tanida, Kyoko Sunuma, Takuya Iwami, Tatsuyoshi Nakanishi, Keita Horiuchi, Kie Kumaishi, Soma Yoshida, Mutsumi Watanabe, Takayuki Tohge, Takamasa Suzuki, Yasunori Ichihashi, Atsushi Takemiya, Nobutoshi Yamaguchi, Takayuki Kohchi, Toshiro Ito<\/p>\n<p class='abstract en'>Abstract\n\n Co-option of gene regulatory networks leads to the acquisition of new cell types and tissues. Stomata, valves formed by guard cells (GCs), are present in most land plants and regulate CO<sub>2<\/sub> exchange. The transcription factor (TF) FAMA globally regulates GC differentiation but also promotes the development of idioblast myrosin cells (MCs), another type of specialized cell along the vasculature essential for Brassicales-specific chemical defenses. Here, we show that the TF gene WASABI MAKER (WSB), directly induced by FAMA, triggers MC differentiation. WSB and STOMATAL CARPENTER 1 (SCAP1), a stomatal lineage\u2013specific direct FAMA target, synergistically promote GC differentiation. wsb mutants lacked MCs, while the wsb scap1 double mutant lacked normal GCs. Evolutionary analyses revealed that WSB is conserved across stomatous angiosperms. Furthermore, the FAMA\u2013WSB positive feedback loop acts as a cell fate switch. We propose that the conserved and reduced transcriptional FAMA\u2013WSB module was co-opted before evolving to induce MC differentiation.<\/p>","protected":false},"excerpt":{"rendered":"Makoto Shirakawa, Tomoki Oguro, Shigeo Sugano, Shohei Yamaoka, Mayu Sagara, Mai Tanida, Kyoko Sunuma, Takuya I [&hellip;]","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3556","post","type-post","status-publish","format-standard","hentry","category-article"],"_links":{"self":[{"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts\/3556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/comments?post=3556"}],"version-history":[{"count":0,"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts\/3556\/revisions"}],"wp:attachment":[{"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/media?parent=3556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/categories?post=3556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/tags?post=3556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}