{"id":204,"date":"2019-11-04T00:00:00","date_gmt":"2019-11-03T15:00:00","guid":{"rendered":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/archives\/204"},"modified":"2021-09-29T12:51:09","modified_gmt":"2021-09-29T03:51:09","slug":"histone-acetylation-orchestrates-wound-induced-transcriptional-activation-and-cellular-reprogramming-in-arabidopsis","status":"publish","type":"post","link":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/archives\/204","title":{"rendered":"Histone acetylation orchestrates wound-induced transcriptional activation and cellular reprogramming in Arabidopsis."},"content":{"rendered":"<p class='author'>Bart Rymen, Ayako Kawamura, Alice Lambolez, Soichi Inagaki, Arika Takebayashi, Akira Iwase, Yuki Sakamoto, Kaori Sako, David S Favero, Momoko Ikeuchi, Takamasa Suzuki, Motoaki Seki, Tetsuji Kakutani, Fran\u00e7ois Roudier, Keiko Sugimoto<\/p>\n<p class='abstract en'>Plant somatic cells reprogram and regenerate new tissues or organs when they are severely damaged. These physiological processes are associated with dynamic transcriptional responses but how chromatin-based regulation contributes to wound-induced gene expression changes and subsequent cellular reprogramming remains unknown. In this study we investigate the temporal dynamics of the histone modifications H3K9\/14ac, H3K27ac, H3K4me3, H3K27me3, and H3K36me3, and analyze their correlation with gene expression at early time points after wounding. We show that a majority of the few thousand genes rapidly induced by wounding are marked with H3K9\/14ac and H3K27ac before and\/or shortly after wounding, and these include key wound-inducible reprogramming genes such as WIND1, ERF113\/RAP2.6\u2009L and LBD16. Our data further demonstrate that inhibition of GNAT-MYST-mediated histone acetylation strongly blocks wound-induced transcriptional activation as well as callus formation at wound sites. This study thus uncovered a key epigenetic mechanism that underlies wound-induced cellular reprogramming in plants.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bart Rymen, Ayako Kawamura, Alice Lambolez, Soichi Inagaki, Arika Takebayashi, Akira Iwase, Yuki Sakamoto, Kao [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts\/204"}],"collection":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/comments?post=204"}],"version-history":[{"count":1,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts\/204\/revisions"}],"predecessor-version":[{"id":235,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/posts\/204\/revisions\/235"}],"wp:attachment":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/media?parent=204"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/categories?post=204"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/tags?post=204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}