{"id":1431,"date":"2023-03-06T11:41:34","date_gmt":"2023-03-06T02:41:34","guid":{"rendered":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/?page_id=1431"},"modified":"2025-03-01T11:53:29","modified_gmt":"2025-03-01T02:53:29","slug":"soturon2022","status":"publish","type":"page","link":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/soturon_abstract\/soturon2022","title":{"rendered":"2022\u5e74\u5ea6 \u5352\u8ad6\u8981\u65e8"},"content":{"rendered":"

drol1<\/i>\u306e\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u306e\u63a2\u7d22\u3068\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u540c\u5b9a<\/h3>\n

\u8352\u7267 \u5927\u4ecb<\/h4>\n
\n

\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306edrol1<\/i>\u5909\u7570\u682a\u306f\u5b50\u8449\u304c\u5e73\u3079\u3063\u305f\u304f\u7d2b\u8272\u3092\u5e2f\u3073\u3066\u3044\u308b\u3001\u767a\u82bd\u3084\u672c\u8449\u306e\u51fa\u73fe\u304c\u9045\u3044\u3001\u6839\u304c\u77ed\u3044\u306a\u3069\u306e\u8868\u73fe\u578b\u3092\u793a\u3059\u3002\u5909\u7570\u682a\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u56e0\u5b50\u306e\u30db\u30e2\u30ed\u30b0\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001drol1<\/i>\u4e2d\u3067\u306fAT-AC \u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u8868\u73fe\u578b\u306b\u3064\u306a\u304c\u308b\u306e\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u305d\u3053\u3067drol1<\/i>\u5909\u7570\u682a\u306e\u8868\u73fe\u578b\u3092\u6291\u5236\u3059\u308b\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u884c\u308f\u308c\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3059\u3067\u306b\u5f97\u3089\u308c\u3066\u3044\u305f\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u306e\u5019\u88dc\u304b\u3089\u4e8c\u6b21\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001\u65b0\u305f\u306b8\u682a\u306e\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u3092\u5f97\u305f\u3002\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u30014\u682a\u306f\u65e2\u77e5\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u56e0\u5b50\u306b\u5909\u7570\u3092\u3082\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\n<\/div>\n

HD2B\u306eAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306eDORL1\u306b\u4f9d\u5b58\u3057\u305f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u6a5f\u69cb\u306e\u89e3\u6790<\/h3>\n

\u4f0a\u85e4\u3000\u4f51\u771f<\/h4>\n
\n

\u771f\u6838\u751f\u7269\u304c\u6301\u3064\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u307b\u307c\u5168\u3066\u306f5\u2019\u7aef\u306e\u5869\u57fa\u914d\u5217\u304cGT\u3067\u30013\u2019\u7aef\u304cAG\u3068\u306a\u3063\u3066\u3044\u308b\u304c\u3001\u4f8b\u5916\u7684\u306bAT\u3067\u59cb\u307e\u308aAC\u3067\u7d42\u308f\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u3002\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306edrol1<\/i>\u5909\u7570\u682a\u3067\u306fAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u7279\u7570\u7684\u306b\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\u304c\u3001DORL1\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u4e0d\u660e\u3067\u3042\u308b\u3002\u305d\u3053\u3067\u3001\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30caHD2B\u907a\u4f1d\u5b50\u306e3\u756a\u76ee\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u3092\u4f7f\u3063\u3066\u3001AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u3069\u306e\u3088\u3046\u306a\u4ed5\u7d44\u307f\u3067DORL1\u4f9d\u5b58\u7684\u306b\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u8abf\u3079\u305f\u3002<\/p>\n

HD2B\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304b\u30894\u756a\u76ee\u306e\u30a8\u30ad\u30bd\u30f3\u307e\u3067\u3092\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u3001\uff4dRFP\u3092\u7e4b\u3044\u3060\u7d44\u307f\u66ff\u3048\u907a\u4f1d\u5b50\u3092\u4f5c\u6210\u3057\u305f\u3002\u307e\u305f\u30013\u756a\u76ee\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u672b\u7aef\u5869\u57fa\u914d\u5217\u3092AT-AC\u304b\u3089GT-AG\u3001GT-AC\u3001AT-AG\u306b\u7f6e\u63db\u3057\u3001\u305d\u308c\u305e\u308c\u690d\u7269\u306b\u5c0e\u5165\u3057\u305f\u3002mRFP\u3092\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001AT-AC\u578b\u306f\u91ce\u751f\u682a\u306e\u307f\u86cd\u5149\u3092\u767a\u3057\u3001GT-AG\u578b\u306fdrol1-1<\/i>\u3067\u3082\u86cd\u5149\u3092\u767a\u3057\u305f\u3002<\/p>\n

\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u3067\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u30d1\u30bf\u30fc\u30f3\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u91ce\u751f\u682a\u306b\u304a\u3044\u3066AT-AC\u3068GT-AG\u306f\u540c\u3058\u4f4d\u7f6e\u3067\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u307b\u3068\u3093\u3069\u3042\u3063\u305f\u304c\u3001AT-AG\u3067\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u306a\u3044\u3082\u306e\u3082\u5897\u3048\u3001GT-AC\u3067\u306f3\u2019\u7aef\u304c\u5909\u308f\u3063\u305f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u591a\u304f\u898b\u3089\u308c\u305f\u3002drol1-1<\/i>\u3067\u306f\u3001GT-AG\u306f\u307b\u307c\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u305f\u304c\u3001AT-AC\u306f\u307b\u3068\u3093\u3069\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u306a\u304b\u3063\u305f\u3002GT-AC\u3068AT-AG\u3082\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u3066\u3044\u306a\u3044\u3082\u306e\u304c\u5897\u3048\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u306fDORL1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u304b\u3081\u3089\u308c\u305f\u3002\u307e\u305f\u30a4\u30f3\u30c8\u30ed\u30f3\u306e3\u2019\u672b\u7aef\u306fAG\u3068\u306a\u308b\u3088\u3046\u306b\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u30d1\u30bf\u30fc\u30f3\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u3001DORL1\u306f5\u2019\u672b\u7aef\u304cAT\u3067\u3042\u308b\u5834\u5408\u306b\u5fc5\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002\n<\/div>\n

NRPA2\u306eAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306eDROL1\u306b\u4f9d\u5b58\u3057\u305f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u6a5f\u69cb\u306e\u89e3\u6790<\/h3>\n

\u7a32\u6ce2\u3000\u53f3\u91cc\u5b50<\/h4>\n
\n

\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306edrol1<\/i>\u5909\u7570\u682a\u306f\u30aa\u30ec\u30aa\u30b7\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u82bd\u5f8c\u306e\u767a\u73fe\u6291\u5236\u304c\u8d77\u304d\u306a\u3044\u5909\u7570\u682a\u3068\u3057\u3066\u5358\u96e2\u3055\u308c\u305f\u3002drol1<\/i>\u5909\u7570\u682a\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308bDROL1\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u3092\u6301\u3064\u907a\u4f1d\u5b50\u306e1\u3064\u306bNRPA2<\/i> (Nuclear RNA Polymerase A2<\/i>)\u304c\u3042\u308a\u3001\u3053\u306eNRPA2<\/i>\u306f\u4e00\u756a\u76ee\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u304cAT-AC\u578b\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001NRPA2<\/i>\u3092\u4f7f\u3063\u3066DROL1\u304cAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u8abf\u3079\u305f\u3002<\/p>\n

NRPA2<\/i>\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304b\u30893\u756a\u76ee\u306e\u30a8\u30ad\u30bd\u30f3\u307e\u3067\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3057\u3001mRFP\u3092\u3064\u306a\u3044\u3060\u3002\u307e\u305fAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u672b\u7aef\u306b\u5869\u57fa\u7f6e\u63db\u3092\u5165\u308c\u3001\u672b\u7aef\u304cGT-AG\u3068\u306a\u308b\u3088\u3046\u306b\u6539\u5909\u578b\u907a\u4f1d\u5b50\u3092\u4f5c\u6210\u3057\u305f\u3002\u305d\u308c\u3089\u3092\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u5c0e\u5165\u3057\u3001RFP\u306e\u767a\u73fe\u3068\u5869\u57fa\u914d\u5217\u304b\u3089\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u6709\u7121\u3092\u8abf\u3079\u305f\u3002RFP\u306e\u767a\u73fe\u306f\u78ba\u8a8d\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u304b\u3063\u305f\u304c\u3001\u62bd\u51fa\u3057\u305fRNA\u3092\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u3067\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u3044\u305a\u308c\u3082\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002AT-AC\u578b\u306fCol\u682a\u3067\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u308b\u3082\u306e\u306e\u3001drol1-1<\/i>\u5909\u7570\u682a\u3067\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u4e00\u65b9GT-AG\u578b\u306fdrol1-1<\/i>\u5909\u7570\u682a\u4e2d\u3067\u3082\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u3055\u308c\u3066\u3044\u305f\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u3001AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u306fDROL1\u3092\u5fc5\u8981\u3068\u3059\u308b\u304cGT-AG\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u306f\u5fc5\u8981\u3068\u3057\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\n<\/div>\n

UXS2\u306eAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306eDROL1\u306b\u4f9d\u5b58\u3057\u305f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u6a5f\u69cb\u306e\u89e3\u6790<\/h3>\n

\u4e95\u4e0a \u6a39<\/h4>\n
\n

\u591a\u304f\u306e\u771f\u6838\u751f\u7269\u306f\u30a4\u30f3\u30c8\u30ed\u30f3\u3092\u6301\u3061\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u5168\u3066\u306f5\u2019\u672b\u7aef\u304cGT\u3067\u30013\u2019\u672b\u7aef\u306fAG\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u3054\u304f\u4e00\u90e8\u306bAT\u3067\u306f\u3058\u307e\u308aAC\u3067\u7d42\u308f\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u304c\u3042\u308b(AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3)\u3002AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306f\u5168\u3066\u306e\u690d\u7269\u3068\u810a\u690e\u52d5\u7269\u3001\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u751f\u7269\u304c\u6301\u3063\u3066\u304a\u308a\u3001\u9032\u5316\u306e\u904e\u7a0b\u3067\u4fdd\u5b58\u3055\u308c\u305f\u4f55\u3089\u304b\u306e\u6a5f\u80fd\u3092\u3082\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n

\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306eDROL1<\/i>\u907a\u4f1d\u5b50\u306fAT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3069\u306e\u3088\u3046\u306a\u50cd\u304d\u304c\u3042\u308b\u306e\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306fUDP\u30ad\u30b7\u30ed\u30fc\u30b9\u5408\u6210\u9175\u7d20(UXS2)\u304c\u3082\u3064AT-AC\u578b\u30a4\u30f3\u30c8\u30ed\u30f3\u3092\u5bfe\u8c61\u306bDROL1\u306e\u6a5f\u80fd\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3002<\/p>\n

UXS2\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304b\u30892\u756a\u76ee\u306e\u30a8\u30ad\u30bd\u30f3\u307e\u3067\u3092G3GFP\u3068\u878d\u5408\u3055\u305b\u305f\u907a\u4f1d\u5b50UXS2p2e-G3GFP\u3092Col\u682a\u3068drol1<\/i>\u5909\u7570\u682a\u3067\u767a\u73fe\u3055\u305b\u305f\u3068\u3053\u308d\u3001Col\u3067\u306f\u6839\u7aef\u306b\u86cd\u5149\u304c\u898b\u3089\u308c\u305f\u304c\u3001drol1<\/i>\u3067\u306f\u5149\u3089\u306a\u304b\u3063\u305f\u3002UXS2\u306e1\u756a\u76ee\u306e\u30a4\u30f3\u30c8\u30ed\u30f3(AT-AC\u578b)\u3092GT-AG\u306b\u7f6e\u63db\u3057\u305f\u3068\u3053\u308d\u3001drol1<\/i>\u306b\u86cd\u5149\u304c\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001AT-AC\u578b\u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306fDROL1\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002<\/p>\n

RT-PCR\u3068\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3067\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u4f4d\u7f6e\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001GT-AG\u306b\u7f6e\u63db\u3057\u305f\u5834\u5408\u3067\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u4f4d\u7f6e\u306b\u5909\u308f\u308a\u304c\u306a\u3044\u3082\u306e\u306e\u30015\u2019\u5074\u3060\u3051\u3092GT\u306b\u7f6e\u63db\u3057\u305f\u5834\u5408\u306f\u30013\u2019\u5074\u304c\u305a\u308c\u3066GT-AG\u3067\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\n<\/p><\/div>\n

DROL1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u90e8\u4f4d\u306e\u540c\u5b9a<\/h3>\n

\u5c0f\u7389 \u99ff\u4ecb<\/h4>\n
\n

\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306eDROL1\u306f\u9175\u6bcd\u306e\u30b9\u30d7\u30e9\u30a4\u30bd\u30bd\u30fc\u30e0\u3092\u69cb\u6210\u3059\u308bU5 snRNP\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308bDIB1\u306e\u30db\u30e2\u30ed\u30b0\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u305f\u3002\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u3082DIB1\u306e\u30aa\u30eb\u30bd\u30ed\u30b0\uff08AtDIB1\uff09\u304c\u5b58\u5728\u3057\u3001DROL1\u3068\u306f\u30a2\u30df\u30ce\u9178\u914d\u5217\u3060\u3051\u3067\u306a\u304f\u3001\u63a8\u5b9a\u3055\u308c\u308b\u7acb\u4f53\u69cb\u9020\u3082\u3088\u304f\u4f3c\u3066\u3044\u308b\u304c\u3001\u4e21\u8005\u306f\u7570\u306a\u308b\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u3002DROL1\u306fAT\u3067\u59cb\u307e\u308aAC\u3067\u7d42\u308f\u308b\u30a4\u30f3\u30c8\u30ed\u30f3\u306b\u7279\u7570\u7684\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u56e0\u5b50\u3067\u3042\u308b\u304c\u3001DIB1\u3068\u306e\u5dee\u304c\u3069\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u9055\u3044\u306b\u3088\u308b\u3082\u306e\u304b\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3002\u305d\u3053\u3067\u3001DROL1\u306e\u4e00\u90e8\u3092DIB1\u306b\u7f6e\u304d\u63db\u3048\u305f\u7d44\u307f\u63db\u3048\u907a\u4f1d\u5b50\u3092\u4f5c\u6210\u3057\u3001\u305d\u308c\u304cdrol1<\/i>\u5909\u7570\u682a\u306e\u8868\u73fe\u578b\u3092\u76f8\u88dc\u3067\u304d\u308b\u304b\u3092\u8abf\u3079\u305f\u3002<\/p>\n

DROL1\u306ecDNA\u306bDROL1\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3068\u30bf\u30fc\u30df\u30cd\u30fc\u30bf\u30fc\u3092\u7d50\u5408\u3057\u305f\u7d44\u307f\u63db\u3048\u907a\u4f1d\u5b50\u3092\u4f5c\u6210\u3057\u305fAtDIB1\u3078\u7f6e\u63db\u3057\u305f\u3082\u306e\u3092\u4f5c\u6210\u3057\u305f\u3002\u3053\u308c\u3089\u3092drol1-1<\/i>\u5909\u7570\u682a\u306b\u5c0e\u5165\u3057\u305f\u3068\u3053\u308d\u3001\u5b8c\u5168\u306aDROL1\u306ecDNA\u3092\u6301\u3064\u3082\u306e\u306f\u91ce\u751f\u682a\u306e\u8868\u73fe\u578b\u3092\u793a\u3057\u305f\u304c\u3001\u5168\u90e8\u307e\u305f\u306f\u4e00\u90e8\u3092AtDIB1\u306b\u7f6e\u63db\u3057\u305f\u3082\u306e\u306fdrol1<\/i>\u3068\u533a\u5225\u3067\u304d\u306a\u304b\u3063\u305f\u3002\n<\/div>\n

U5-40k\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u306b\u5fc5\u8981\u306a\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u540c\u5b9a<\/h3>\n

\u9f4b\u85e4 \u671d\u8863<\/h4>\n
\n

\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306e\u7a2e\u5b50\u4e2d\u306e\u7d30\u80de\u306b\u306f\u3001\u6cb9\u8102\u3092\u84c4\u7a4d\u3059\u308b\u305f\u3081\u306e\u30aa\u30a4\u30eb\u30dc\u30c7\u30a3\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u5c0f\u5668\u5b98\u304c\u5b58\u5728\u3057\u3001\u305d\u306e\u819c\u306b\u30aa\u30ec\u30aa\u30b7\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u591a\u91cf\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u3002\u30aa\u30ec\u30aa\u30b7\u30f3\u306e\u767a\u73fe\u306f\u7a2e\u5b50\u767b\u719f\u671f\u306b\u306f\u9ad8\u3044\u304c\u3001\u767a\u82bd\u6642\u306b\u306f\u6291\u5236\u3055\u308c\u308b\u3002\u767a\u82bd\u5f8c\u306e\u30aa\u30ec\u30aa\u30b7\u30f3\u306e\u767a\u73fe\u91cf\u3092\u6307\u6a19\u306b\u5909\u7570\u682a\u306e\u63a2\u7d22\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u767a\u82bd\u5f8c\u3082\u6291\u5236\u3055\u308c\u306a\u3044drol1-1<\/i>\u5909\u7570\u682a\u304c\u5358\u96e2\u3055\u308c\u305f\u3002drol1<\/i>\u5909\u7570\u682a\u306f\u5f62\u614b\u5f62\u6210\u306b\u3082\u5f71\u97ff\u304c\u3042\u308a\u3001\u91ce\u751f\u578b\u682a\u3068\u6bd4\u8f03\u3057\u3066\u751f\u9577\u304c\u9045\u3044\u3001\u5b50\u8449\u304c\u5e73\u305f\u3044\u3001\u8449\u306e\u88cf\u5074\u306f\u7d2b\u8272\u3092\u5e2f\u3073\u3066\u3044\u308b\u3068\u3044\u3046\u8868\u73fe\u578b\u3092\u793a\u3057\u305f\u3002<\/p>\n

DROL1\u306e\u6a5f\u80fd\u3092\u8abf\u3079\u308b\u305f\u3081\u306bdrol1-1<\/i>\u5909\u7570\u682a\u306e\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u884c\u308f\u308c\u3001\u5f97\u3089\u308c\u305f\u682a\u306e\u4e00\u3064\u304cds1-1<\/i>(\u65e7\u540d#8-5)\u3067\u3001\u305d\u308c\u304c\u6301\u3064\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u907a\u4f1d\u5b50\u3092sudl1-1<\/i>\u3068\u3057\u305f\u3002ds1-1<\/i>\u306e\u30b2\u30ce\u30e0\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001U5 snRNP\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u5909\u7570\u304c\u3042\u3063\u305f\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304cdrol1<\/i>\u306e\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u3068\u306a\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3092\u4f7f\u3063\u3066\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u3068\u3053\u308d\u3001\u30d5\u30ec\u30fc\u30e0\u30b7\u30d5\u30c8\u3092\u8d77\u3053\u3059\u3088\u3046\u306a\u5909\u7570\u306f\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u305b\u305a\u3001\u81f4\u6b7b\u3068\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002<\/p>\n

\u672c\u7814\u7a76\u3067\u306fSUDL1\u306e\u5909\u7570\u304cdrol1<\/i>\u306b\u81f4\u6b7b\u6027\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3092\u5229\u7528\u3057\u3066\u305d\u306e\u6a5f\u80fd\u306b\u91cd\u8981\u306a\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3092\u8a66\u307f\u305f\u3002SUDL1\u306eC\u672b\u5074\u3092\u524a\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092drol1<\/i>\u5909\u7570\u682a\u3067\u767a\u73fe\u3055\u305b\u305f\u3068\u304d\u306b\u3001\u305d\u306e\u8868\u73fe\u578b\u3092\u6291\u5727\u3067\u304d\u308b\u304b\u3092\u5b9f\u9a13\u7684\u306b\u8abf\u3079\u305f\u3002\u305d\u306e\u7d50\u679c\u30013\u6bb5\u968e\u306b\u5206\u3051\u3066\u30a2\u30df\u30ce\u9178\u3092\u524a\u3063\u305f\u304c\u3001\u6700\u592738\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u3092\u524a\u3063\u305f\u5834\u5408\u3067\u3082\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002\n<\/div>\n","protected":false},"excerpt":{"rendered":"

drol1\u306e\u30b5\u30d7\u30ec\u30c3\u30b5\u30fc\u306e\u63a2\u7d22\u3068\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u540c\u5b9a \u8352\u7267 \u5927\u4ecb \u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306edrol1\u5909\u7570\u682a\u306f\u5b50\u8449\u304c\u5e73\u3079\u3063\u305f\u304f\u7d2b\u8272\u3092\u5e2f\u3073\u3066\u3044\u308b\u3001\u767a\u82bd\u3084\u672c\u8449\u306e\u51fa\u73fe\u304c\u9045\u3044\u3001\u6839\u304c\u77ed\u3044\u306a\u3069\u306e\u8868\u73fe\u578b\u3092\u793a\u3059\u3002\u5909\u7570\u682a\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306f\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u56e0\u5b50 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2236,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/pages\/1431"}],"collection":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/comments?post=1431"}],"version-history":[{"count":14,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/pages\/1431\/revisions"}],"predecessor-version":[{"id":1987,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/pages\/1431\/revisions\/1987"}],"up":[{"embeddable":true,"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/pages\/2236"}],"wp:attachment":[{"href":"http:\/\/biochemistry.isc.chubu.ac.jp\/labo\/suzuki\/wp-json\/wp\/v2\/media?parent=1431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}